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Comparing two combination regimens (A and B), Regimen B, which employed a 28-day cycle with split-dose oral Vorinostat (days 1–7 and 15–21) and dose-dense, lower-dose ixabepilone (days 2, 9, and 16), demonstrated superior clinical efficacy compared to Regimen A (21-day cycle)

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Publication concentration A large proportion of published work originates from a small network of affiliated investigators, reducing the independence of the evidence base