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Its anti-inflammatory effects were demonstrated by Yang et al., who observed reduced levels of the pro-inflammatory cytokines IL-1β, IL-6, and TNF-α in the serum of mice treated with posaconazole, suggesting its capacity to attenuate this antifungal drug-adverse effects

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AOD9604 has been studied in pre-clinical cartilage biology and osteoarthritis models , characterising effects on chondrocyte metabolism, proteoglycan synthesis, cartilage matrix preservation, and joint tissue homeostasis that extend beyond the adipose tissue lipolytic biology for which the compound was originally developed