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Those domains are responsible for binding host proteins essential for both viral replication and immune evasion ( The principal function attributed to ICP34.5 involves enhancing viral propagation across peripheral tissues alongside central nervous systems, contributing significantly toward HSV, and inducing neurovirulence via various mechanisms including protein phosphatase I (PPI) dephosphorylating eIF2α, thus preventing shutoff from host protein synthesis while enabling continuous production ( Moreover, ICP34.5 inhibits antiviral signaling pathways ensuring persistent infections

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